Therapeutic Angiogenesis and Vasculogenesis for Ischemic Disease

Therapeutic angiogenesis and vasculogenesis for ischemic disease: part II: cell-based therapies.

Cell Therapy For Therapeutic Vascularization Endothelial Progenitor Cells and Postnatal Vasculogenesis: Experimental Evidence The option of performing full-scale endothelial cell transplantation to optimize local neovascularization is daunting if even feasible. An alternative, attractive strategy is designed to exploit the conceptual notion that endothelial cells and hematopoietic stem cells we...

Therapeutic angiogenesis and vasculogenesis for ischemic disease. Part I: angiogenic cytokines.

Deprivation of oxygen and nutrients provides a serious threat for tissue viability. Nature’s response to the development of profound tissue ischemia includes the upregulation of angiogenic growth factors and mobilization of circulating cellular elements that together enable development of an accessory vasculature.1 The involved paradigm, not surprisingly, recapitulates many aspects of embryonic...

Angiogenesis and vasculogenesis for therapeutic neovascularization.

Peripheral blood of adult species contains endothelial progenitor cells (EPCs) that participate in neovascularization, consistent with postnatal vasculogenesis. EPCs can be isolated not only from peripheral blood but also from bone marrow and human umbilical cord blood. In vitro culture-expanded EPCs participate in endothelial network formation (capillary formation) in vitro, and transplanted E...

Therapeutic angiogenesis in ischemic heart disease.

The de-novo formation of vessels (angiogenesis) and the remodelling of preexisting collateral vessels (arteriogenesis) are processes that occur naturally in ischemic heart disease. Promoting these processes by administration of various substances or other physical stimuli (therapeutic angiogenesis) may provide a future strategy for the treatment of ischemic vascular diseases. Mechanisms of angi...

Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization.